Welcome to my (minimal) scientific homepage - Toni Ingolf Gossmann

I am a researcher in the field of evolutionary biology. I work on different topics that are all connected by my passion for knowledge and creativity. At the moment I am at Bielefeld University as an Independent Career Fellow.

Research Interests

My work focuses on approaches and data analysis to identify imprints of selection in natural populations.

Population Genomics

Comparative Genomics

Functional Genomics

Contact me

Toni Ingolf Gossmann

Department of Animal & Plant Sciences
Western Bank
University of Sheffield
Sheffield, S10 2TN
United Kingdom


Twitter Publons

Current Collaborators

David Waxman @ Fudan University (China)
Mathias Ziegler @ University of Bergen (Norway)
Markus Ralser @ University of Cambridge (UK)
Ines Heiland @ University of Tromsø (Norway)
Mirre Simons @ University of Sheffield (UK)
Veronika Laine @ NIOO-KNAW (Netherlands)
Kees van Oers @ NIOO-KNAW (Netherlands)
Miriam Liedvogel @ Max Planck Institute Ploen (Germany)
Rhonda Snook @ University of Stockholm (Sweden)
Alexander Suh @ University of Uppsala (Sweden)

List of Publications

Google Scholar Pubmed ResearchGate


Mathias Bockwoldt, Dorothée Houry, Marc Niere, Toni I. Gossmann, Ines Reinartz, Alexander Schug, Mathias Ziegler, Ines Heiland: Identification of evolutionary and kinetic drivers of NAD-dependent signaling. Proceedings of the National Academy of Sciences 07/2019;, DOI:10.1073/pnas.1902346116

Toni I Gossmann, Achchuthan Shanmugasundram, Stefan Thomas Börno, Ludovic Duvaux, Christophe Lemaire, Heiner Kuhl, Sven Klages, Lee D Roberts, Sophia Schade, Johanna M Gostner, Falk Hildebrand, Jakob Vowinckel, Coraline Bichet, Michael Mülleder, Enrica Calvani, Aleksej Zelezniak, Peer Bork, Dominique Allainé, Aurélie Cohas, John J. Welch, Bernd Timmermann, Markus Ralser: Ice-Age Climate Adaptations Trap the Alpine Marmot in a State of Low Genetic Diversity. Current Biology 05/2019; 29(10)., DOI:10.1016/j.cub.2019.04.020

Timothy L. Karr, Helen Southern, Matthew A. Rosenow, Toni I. Gossmann, Rhonda R. Snook: The Old and the New: Discovery Proteomics Identifies Putative Novel Seminal Fluid Proteins in Drosophila. Molecular & Cellular Proteomics 02/2019; 18(Supplement 1):mcp.RA118.001098., DOI:10.1074/mcp.RA118.001098

Falk Hildebrand, Lucas Moitinho-Silva, Sonja Blasche, Martin Thomas Thomas Jahn, Toni Ingolf Gossmann, Jaime Heuerta Cepas, Rajna Hercog, Mechthild Luetge, Mohammad Bahram, Anna Pryszlak, Renato J Alves, Sebastian M Waszak, Ana Zhu, Lumeng Ye, Paul Igor Costea, Steven Aalvink, Clara Belzer, Sofia K Forslund, Shinichi Sunagawa, Ute Hentschel, Christoph Merten, Kiran Raosaheb Patil, Vladimir Benes, Peer Bork: Antibiotics-induced monodominance of a novel gut bacterial order. Gut 01/2019;, DOI:10.1136/gutjnl-2018-317715

Veronika N. Laine, Toni I. Gossmann, Kees van Oers, Marcel E. Visser, Martien A. M. Groenen:Exploring the unmapped DNA and RNA reads in a songbird genome. BMC Genomics 12/2019; 20(1)., DOI:10.1186/s12864-018-5378-2


Toni I Gossmann, Mathias Bockwoldt, Lilith Diringer, Friedrich Schwarz, Vic-Fabienne Schumann: Evidence for Strong Fixation Bias at 4-fold Degenerate Sites Across Genes in the Great Tit Genome. Frontiers in Ecology and Evolution; 11/2018; 6:203., DOI:10.3389/fevo.2018.00203

Arina Afanasyeva, Mathias Bockwoldt, Christopher R Cooney, Ines Heiland, Toni I Gossmann: Human long intrinsically disordered protein regions are frequent targets of positive selection. Genome Research 06/2018; 28(7):gr.232645.117., DOI:10.1101/gr.232645.117


Pádraic Corcoran*, Toni I Gossmann*, Henry J Barton, Jon Slate, Kai Zeng: Determinants of the efficacy of natural selection on coding and noncoding variability in two passerine species. Genome Biology and Evolution 10/2017;, DOI:10.1093/gbe/evx213 (* co-first authors)

Dennis Kappei, Marion Scheibe, Maciej Paszkowski-Rogacz, Alina Bluhm, Toni I Gossmann, Sabrina Dietz, Mario Dejung, Holger Herlyn, Frank Buchholz, Matthias Mann, Falk Butter: Phylointeractomics reconstructs functional evolution of protein binding. Nature Communications 02/2017; 8:14334., DOI:10.1038/ncomms14334

Hassan Shafiey, Toni I Gossmann, David Waxman: Evolutionary control: Targeted change of allele frequencies in natural populations using externally directed evolution. Journal of Theoretical Biology 01/2017; 419., DOI:10.1016/j.jtbi.2017.01.023


Toni I Gossmann*, Dounia Saleh*, Marc W. Schmid, Michael A. Spence, Karl J. Schmid: Transcriptomes of plant gametophytes have a higher proportion of rapidly evolving and young genes than sporophytes. Molecular Biology and Evolution 03/2016; DOI:10.1093/molbev/msw044 (* co-first authors)

Veronika N Laine*, Toni I Gossmann*, Kyle M Schachtschneider*, Colin J Garroway, Ole Madsen, Koen JF Verhoeven, Victor de Jager, Hendrik-Jan Megens, Wesley C Warren, Patrick Minx, Richard PMA Crooijmans, Padraic Corcoran, The Great Tit HapMap Consortium, Ben C Sheldon, Jon Slate, Kai Zeng, Kees van Oers, Marcel E Visser, Martien AM Groenen: Evolutionary signals of selection on cognition from the great tit genome and methylome. Nature Communications 01/2016; 7:10474. DOI:10.1038/ncomms10474 (* co-first authors)

Lei Zhao, Toni I Gossmann, David Waxman: A modified Wright-Fisher model that incorporates Ne: A variant of the standard model with increased biological realism and reduced computational complexity. Journal of Theoretical Biology 01/2016; DOI:10.1016/j.jtbi.2016.01.002

before 2016

Toni I Gossmann, Anna W Santure, Ben C Sheldon, Jon Slate, Kai Zeng: Highly Variable Recombinational Landscape Modulates Efficacy of Natural Selection in Birds. Genome Biology and Evolution 07/2014; 6(8). DOI:10.1093/gbe/evu157

Toni I Gossmann, Mathias Ziegler: Sequence divergence and diversity suggests ongoing functional diversification of vertebrate NAD metabolism. DNA Repair 07/2014; 23. DOI:10.1016/j.dnarep.2014.07.005

Toni I Gossmann, David Waxman, Adam Eyre-Walker: Fluctuating Selection Models and Mcdonald-Kreitman Type Analyses. PLoS ONE 01/2014; 9(1):e84540. DOI:10.1371/journal.pone.0084540

Toni I Gossmann, Marc W Schmid, Ueli Grossniklaus, Karl J Schmid: Selection-Driven Evolution of Sex-Biased Genes Is Consistent with Sexual Selection in Arabidopsis thaliana. Molecular Biology and Evolution 11/2013; 31(3). DOI:10.1093/molbev/mst226

Toni I Gossmann, Peter D Keightley, Adam Eyre-Walker: The Effect of Variation in the Effective Population Size on the Rate of Adaptive Molecular Evolution in Eukaryotes. Genome Biology and Evolution 03/2012; 4(5):658-67. DOI:10.1093/gbe/evs027

Toni I Gossmann, Mathias Ziegler, Pål Puntervoll, Luis F de Figueiredo, Stefan Schuster, Ines Heiland: NAD+ biosynthesis and salvage - A phylogenetic perspective. FEBS Journal 03/2012; 279(18):3355-63. DOI:10.1111/j.1742-4658.2012.08559.x

Toni I Gossmann, Karl J Schmid: Selection-Driven Divergence After Gene Duplication in Arabidopsis thaliana. Journal of Molecular Evolution 10/2011; 73(3-4):153-65. DOI:10.1007/s00239-011-9463-2

Toni I Gossmann, Megan Woolfit, Adam Eyre-Walker: Quantifying the Variation in the Effective Population Size Within a Genome. Genetics 09/2011; 189(4):1389-402. DOI:10.1534/genetics.111.132654

Luis F de Figueiredo, Toni I Gossmann, Mathias Ziegler, Stefan Schuster: Pathway Analysis of NAD+ metabolism. Biochemical Journal 07/2011; 439(2):341-8. DOI:10.1042/BJ20110320

Corinna Lau, Christian Dölle, Toni I Gossmann, Line Agledal, Marc Niere, Mathias Ziegler: Isoform-specific targeting and interaction domains (ISTIDs) in human nicotinamide mononucleotide adenylyltransferases (NMNATs). Journal of Biological Chemistry 04/2010; 285(24):18868-76. DOI:10.1074/jbc.M110.107631

Toni I Gossmann, Bao-Hua Song, Aaron J Windsor, Thomas Mitchell-Olds, Christopher J Dixon, Maxim V Kapralov, Dmitry A Filatov, Adam Eyre-Walker: Genome Wide Analyses Reveal Little Evidence for Adaptive Evolution in Many Plant Species. Molecular Biology and Evolution 03/2010; 27(8):1822-32. DOI:10.1093/molbev/msq079